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2022 Economic Census / NAICS 325413

In-vitro diagnostic substance manufacturing

The four largest firms in In-vitro diagnostic substance manufacturing accounted for 48.8% of the industry's 2022 sales, value of shipments, or revenue, and its concentration (HHI 752) ranks 130 of 679 detailed industries in the Economic Census. What is HHI?

National employer-firm concentration for this detailed industry, measured from sales, value of shipments, or revenue. Census categories are statistical groupings, not necessarily antitrust markets.

Detailed industryManufacturingUpper quartile

Revenue-based HHI

752.2

325413
03,500
Same-level median 28481th percentile

National rank

#130

of 679 published

Sector rank

#72

of 271 published

Largest 4 firms

48.8%

Share of industry revenue

Revenue

$23.1B

Sales, shipments, or revenue

Employer firms

207

207

Employment

41.7K

41,726

Five-year concentration trace

Same code, hierarchy, sector, and label in both Census tables.

Trace relative position
2017 HHI928.2
2022 HHI752.2
Published change-176
Open history profile
  • GeographyUnited StatesNational firm totals
  • UniverseEmployer firmsFirms with payroll
  • MeasurementRevenue concentrationSales, shipments, or revenue
  • Permitted useScreening onlyNot a legal market definition

Two-vintage industry profile

How this published industry row changed from 2017 to 2022

Inspect six Census measures, publication status, and this row's signed-change position among strict same-level peers.

Strict code + label matchNAICS 325413

Herfindahl-Hirschman Index / HHI points

-176 pts-19% from 2017

Same-level change rank

#520 of 5434.2th percentile
2017 Economic Census928.2
2022 Economic Census752.2
National rank
#520 of 543
Sector rank
#225 of 238
National coverage
543 of 789
Sector coverage
238 of 327

Comparison evidence

The NAICS code, hierarchy depth, sector, and label are identical in both Census tables.

Five-year deltas are published only for rows whose NAICS code and industry label are identical in the 2017 and 2022 Census tables. This strict match is a conservative screening rule, not an official NAICS concordance or evidence of causation. Revenue changes are nominal and are not adjusted for inflation.

Census formation and sector context

The broader Manufacturing formation environment

60 monthly observations for parent sector NAICS 31-33; none are assigned to this narrower industry.
Parent-sector context
Business Applications
7,842
Jul 2026 monthly count
Application annual change
+22.1%
Same month one year earlier
U.S. application share
1.4%
Share of national applications
High-propensity mix
31.2%
2,445 applications
Projected formations
553
Modeled four-quarter source projection
Establishment entry rate
6.9%
2023 annual BDS rate

Monthly source trajectory

Applications and high-propensity applications

Aug 2021 to Jul 2026
Business ApplicationsHigh-Propensity Business Applications
Sixty-month business application trajectory for ManufacturingBusiness Applications and the high-propensity subset share one count axis. The chapter describes the selected industry's broader parent sector.20K15K10K5K0Aug 2021Nov 2022Feb 2024May 2025Jul 2026
83,371 applications / latest 12 months28,261 high-propensity / latest 12 months

Source clocks

Four releases, three measurement systems

Business Formation Statistics
2026-07
monthly applications and projected formations
Business Dynamics Statistics
2023
annual employer-establishment flows
Economic Census structure
2022
median across detailed-industry HHI rows
Strict concentration history
2017-2022
same-code and same-label detailed pairs
Broader-sector boundary

Every formation and business-dynamics reading in this chapter describes the broader Manufacturing sector (NAICS 31-33), not In-vitro diagnostic substance manufacturing (NAICS 325413) by itself. This atlas joins only exact broad-sector NAICS contracts across three separate Census systems: monthly Business Formation Statistics, annual Business Dynamics Statistics, and Economic Census industry structure. The release clocks, populations, denominators, and measures remain distinct. Positions are descriptive context, not composite competition scores, causal estimates, legal antitrust markets, or evidence that applications, entry, concentration, and competitive effects are interchangeable.

BLS labor and payroll context

The broader Manufacturing labor environment

The parent NAICS 31-33 bridge supplies context only; no reading is assigned to this narrower industry.
Parent-group context
Job openings
3.7%
Jun 2026 JOLTS rate
Hires
2.6%
Jun 2026 JOLTS rate
Quits
1.5%
Jun 2026 JOLTS rate
Layoffs + discharges
0.7%
Jun 2026 JOLTS rate
All employees
12.6M
12,611 thousand payroll jobs
Weekly hours
40.4
+0.2 hrs from year earlier
Hourly earnings
$36.87
+3.8% from year earlier

JOLTS worker flows

Openings and quits on native rate scales

Jul 2021 to Jun 2026
Job openings rateQuits rate
Sixty-month JOLTS openings and quits ratesJob openings and quits rates for the mapped Manufacturing source group. The measures keep their published denominators and are not a labor-market power score.8.0%6.0%4.0%2.0%0.0%Jul 2021Oct 2022Jan 2024Apr 2025Jun 2026
+0.7 pp openings / year earlier+0.1 pp quits / year earlier

CES payroll context

Payroll jobs and nominal earnings, indexed

Aug 2021 = 100
Payroll jobsHourly earnings
Sixty-month CES payroll jobs and hourly earnings indexesPayroll jobs and nominal average hourly earnings for the mapped Manufacturing source group, each independently indexed to 100 in the first displayed month. Native levels remain in the readouts.13012111310495Aug 2021Nov 2022Feb 2024May 2025Jul 2026
-0.1% payroll jobs / year earlier+3.8% nominal earnings / year earlier

Declared classification bridge

One profile, two source-owned industry groups

Selected Census parent
NAICS 31-33
Manufacturing
JOLTS group
300000
Manufacturing
CES supersector
30
Manufacturing
Mapped Census sectors
1
31-33

Independent release clocks

Two monthly systems, no merged series

JOLTS worker flows
2026-06
60 displayed months · latest preliminary
CES payroll context
2026-07
60 displayed months · latest preliminary
Parent-group boundary

Every JOLTS and CES reading in this chapter describes the broader Manufacturing and Manufacturing BLS groups mapped through parent sector NAICS 31-33, not In-vitro diagnostic substance manufacturing (NAICS 325413) by itself. JOLTS industry rates describe national labor demand and worker-flow activity in broad BLS industry groups. They do not measure employer concentration, monopsony power, wages, bargaining power, job quality, local labor-market conditions, worker substitutability, a legal labor market, or the competitive cause of a change. The job openings rate uses employment plus openings as its denominator. Hires, quits, and layoffs and discharges use employment. Rates may be compared across published industry groups within the same measure, but different measures must not be added together or treated as a common flow balance. CES employment, hours, and earnings describe national payroll jobs and establishment averages in broad private-industry groups. They do not measure unique workers, vacancies, employer concentration, monopsony power, bargaining power, job quality, a local or occupational labor market, a legal antitrust market, or the competitive cause of a change. All-employee hourly earnings are current-dollar averages and are not adjusted for inflation. Changes can reflect shifts in industry and worker composition. Employment is reported in thousands of payroll jobs, so multiple jobholders may be counted more than once. Compare industries only within the same published measure; do not add or ratio the three measures into a common score. The two releases remain separate and are not combined into a labor-market, monopsony, competition, welfare, or causal score.

BLS manufacturing production context

The broader manufacturing production environment

The parent NAICS 31-33 bridge supplies context only; no reading is assigned to this narrower industry.
Parent-sector context
Productivity
+0.9%
Index 100.208 · 2017=100
Real output
+1.3%
Index 99.847 · 2017=100
Hours
+0.4%
Index 99.640 · 2017=100
Compensation
+4.5%
Index 139.188 · 2017=100
Real compensation
+0.6%
Index 102.147 · 2017=100
Unit labor costs
+3.5%
Index 138.898 · 2017=100

Published index paths

Labor productivity on the shared 2017=100 base

BLS index, 2017=100
ManufacturingDurable manufacturingNondurable manufacturing
20-quarter manufacturing labor-productivity indexesBLS labor-productivity series for manufacturing, durable manufacturing, and nondurable manufacturing. The scopes are aggregate classification context and are not competition measures.1021009896942021 Q32022 Q32023 Q32024 Q32025 Q32026 Q2
100.208Manufacturing100.131Durable manufacturing99.680Nondurable manufacturing

Published four-quarter change

Labor productivity change across three scopes

2021 Q3 to 2026 Q2
ManufacturingDurable manufacturingNondurable manufacturing
20-quarter manufacturing labor-productivity four-quarter changesBLS labor-productivity series for manufacturing, durable manufacturing, and nondurable manufacturing. The scopes are aggregate classification context and are not competition measures.5.0%2.3%-0.5%-3.3%-6.0%2021 Q32022 Q32023 Q32024 Q32025 Q32026 Q2
+0.9%Manufacturing+2.2%Durable manufacturing-0.3%Nondurable manufacturing

Latest native measure matrix

One quarter, six measures, three source scopes

2026 Q2 · preliminary
Latest BLS manufacturing productivity and labor-cost indexes and four-quarter changes
BLS scopeProductivityReal outputHoursCompensationReal compensationUnit labor costs
ManufacturingPRS 3000+0.9%100.208 index+1.3%99.847 index+0.4%99.640 index+4.5%139.188 index+0.6%102.147 index+3.5%138.898 index
Durable manufacturingPRS 3100+2.2%100.131 index+3.1%99.837 index+0.9%99.707 index+5.5%141.029 index+1.7%103.498 index+3.3%140.845 index
Nondurable manufacturingPRS 3200-0.3%99.680 index-0.6%99.218 index-0.4%99.537 index+2.2%135.573 index-1.5%99.494 index+2.5%136.009 index

Declared classification bridge

Narrow industry beside its broad production context

Selected profile
NAICS 325413
In-vitro diagnostic substance manufacturing
Canonical parent
NAICS 31-33
Manufacturing
BLS source scopes
3
Manufacturing / Durable manufacturing / Nondurable manufacturing
Displayed contract
20 quarters
6 measures · 2017=100
Parent-sector bridge boundary

Every reading in this chapter describes broad manufacturing aggregates mapped through parent sector NAICS 31-33, not In-vitro diagnostic substance manufacturing (NAICS 325413) by itself. No BLS value is allocated to this narrower industry. Major-sector productivity and cost indexes describe aggregate U.S. production, hours, and labor compensation. They do not measure market concentration, markups, profits, employer power, bargaining power, innovation, product quality, a legal antitrust market, or the competitive cause of a change. All measures are seasonally adjusted BLS indexes with 2017=100, but sector boundaries and output concepts still differ. Manufacturing uses sectoral output while business, nonfarm business, and nonfinancial corporations use value-added output. Four-quarter changes are derived from published indexes and are descriptive, not causal. Do not average the measures into a composite score. The six measures and three scopes remain separate and are not combined into a productivity, labor-cost, market-power, competitiveness, welfare, or causal score.

BEA industry output context

The broader Manufacturing output environment

Parent NAICS 31-33 supplies context only; no BEA value is assigned to this narrower industry.
Parent-sector context
GDP share
9.4%
2025 current-dollar composition
Real growth
+6.9%
2026-Q1 annualized BEA convention
Growth contribution
+0.63 pp
2026-Q1 contribution to real GDP growth
Real quantity index
116.1
2026-Q1 / 2017=100
Current value added
$3T
2026-Q1 seasonally adjusted annual rate

Annual composition trajectory

Share of current-dollar GDP

1997-2025
Manufacturing annual share of current-dollar GDPBEA value-added share from 1997 through 2025. This is an accounting composition measure, not a market share.17.0%14.8%12.5%10.3%8.0%19972004201120182025
16.1%1997-6.7 pplong-run shift9.4%2025
Parent-sector boundary

Every BEA reading in this chapter describes parent sector Manufacturing (NAICS 31-33), not In-vitro diagnostic substance manufacturing (NAICS 325413) by itself. No value is allocated to the narrower industry. BEA value added measures an industry's contribution to GDP. It is not sales, gross output, profit, a markup, market share, concentration, a legal antitrust market, or evidence of competitive harm or causation. Current-dollar value-added shares reflect both prices and quantities. Real value added uses chained 2017 dollars and is suitable for growth comparisons, but chained-dollar industry components are not additive. Quarterly levels are seasonally adjusted at annual rates, and quarterly growth and contribution measures retain BEA's published annualized convention. The BEA table contains nested industries, cross-industry aggregates, and addenda. Only the 20 major-industry rows form the composition view; summing those rows with their children, parent aggregates, or addenda would double count activity.

BEA domestic production requirements

Production industries inside the broader Manufacturing sector

Parent NAICS 31-33 supplies a classification directory only; no requirement coefficient is assigned to this narrower profile.
Sector directory only
BEA lines in scope
19
inside NAICS 31-33
Annual matrices
28
1997-2024
Raw matrix cells
37,772
retained without aggregation
Net requirement
Not constructed
not additive across buyer columns
Own requirement
Not constructed
no sector diagonal constructed
Directory boundary

This chapter is a directory of 19 BEA summary industries classified inside parent sector Manufacturing (NAICS 31-33). No coefficient is averaged, summed across buyer columns, or allocated to In-vitro diagnostic substance manufacturing (NAICS 325413). A domestic total-requirements coefficient reports the U.S. output required from the supplier-row industry, directly and indirectly, per dollar of output delivered to final use by the buyer-column industry. It is not observed spending, a contract, a firm supplier link, market share, concentration, a legal antitrust market, competitive harm, or causation. Rows are supplying industries and columns are buyer industries delivering output to final use. Reading down a buyer column traces upstream requirements; reading across a supplier row traces the industries whose final-use output requires that supplier. BEA requirements tables use fixed input structures, constant returns to scale, and no input substitution. Coefficients are average, ex-post industry relationships; domestic import adjustments are estimated and do not identify firm-specific sourcing. Diagonal values include an industry's own direct and indirect requirements. Published negative coefficients are retained as accounting adjustments and must not be ranked as positive supply requirements.

Firm concentration ladder

How much revenue the largest firms hold

Each rung widens the group of largest firms included in the Census concentration ratio.

CR4Four largest firms48.8%
CR8Eight largest firms65.6%
CR20Twenty largest firms86.2%
CR50Fifty largest firms96.1%

Same-level benchmark

Position in the hierarchy

MeasureThis rowMedian
HHI752.2284
CR448.8%30.6%
Revenue$23.1B$14.5B
Firms2071.2K

HHI distance from median

+468.2

NAICS hierarchy

Move up or down the classification tree

Level 6 of 6

Direct child categories

This is the most detailed six-digit category.

Reciprocal fingerprint network

Position in the national industry graph

A link appears only when both industries rank one another among their three nearest complete Census fingerprints across all six published measures.

2022 · all-six lens · mutual top 3
Mutual degree
2
reciprocal 2022 links
Component reach
13
component-12
Link mix
2 same / 0 cross
same-sector / cross-sector
Graph coverage
679/899
673 reciprocal edges
2022 ego networkLines are reciprocal top-three links325413
3254133261603.0 pts3221206.4 pts
Selected industrySame sectorCross-sector

Current reciprocal ledger

2 retained graph neighbors

Fixed-cohort network change

2017 to 2022 reciprocal link turnover

Both graphs use the same 543 complete strict-match industries. The fixed-cohort 2022 degree can differ from the larger current snapshot above.

TransitionSame link setSame links
Mutual degree2 → 2net 0
Component46 → 6net -40 nodes
Neighbor retention100.0%2 of 2 retained
Turnover00 added / 0 removed

Turnover classes describe reciprocal graph states, not economic entry, exit, stability, or structural transformation. Connected and isolated refer only to the selected top-three fingerprint graph. Every class is derived from retained, added, and removed links under the fixed-cohort network-change contract.

Nearest structural neighbors

Comparable fingerprints across the economy

Smallest mean national-percentile gaps across HHI, CR4, CR8, revenue, employment, and employer firms, using the same published dimensions as this row.

Evidence access

Reuse this exact row

Source citation

U.S. Census Bureau, 2022 Economic Census, EC2200SIZECONCEN: Selected Sectors - Concentration of Largest Firms for the United States, released April 2025.

Industry screen, not market conclusion

A NAICS industry is a statistical classification, not a legally defined antitrust market. Use these national revenue concentration measures to screen where deeper product and geographic market analysis may be warranted, not to infer market power or liability.

Market definition method
In-vitro diagnostic substance manufacturing industry concentration (NAICS 325413) | Antitrust Radar